Abstract
Influenza, a severe viral infection of the respiratory system, is responsible for a significant morbidity and mortality due to both annual epidemics and unpredictable pandemics. In the United States alone, 10-20% of the population is affected every year, which results in approximately 110,000 hospitalizations and more than 20,000 deaths with an estimated cost of U.S. $12 billion.1 In addition to the annual occurrence of the disease, there is a growing concern that a worldwide pandemic will inevitably happen within the next few years. Since the 1500s, the world has seen 22 influenza pandemics, * Phone number: 1-(860)-6869021. Fax number: 1-(860)-7154978. E-mail address: Javier.Magano@Pfizer.com. Chem. Rev. XXXX, xxx, 000–000 A
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