Abstract
AbstractDiabetes mellitus, commonly referred to as diabetes, is a persistent medical condition that contributes to a significant global mortality rate and various associated complications in individuals. To address the needs of those diagnosed with type 2 diabetes, the pharmaceutical market offers a range of antidiabetic medications. Among these options, gliflozins stand out as highly efficacious therapeutic agents for the management of type 2 diabetes. These medications inhibit the function of sodium–glucose linked transporter (SGLT) enzymes in the kidneys, effectively halting the reabsorption of sugar and leading to a reduction in the overall glucose load within the bloodstream. This review aims at providing a comprehensive overview of the various syntheses for each of the gliflozin drugs reported in the literature and also summarizes the synthetic advancements in this area to date.1 Introduction2 Synthesis of Gliflozins2.1 Canagliflozin2.2 Dapagliflozin2.3 Ipragliflozin2.4 Empagliflozin2.5 Luseogliflozin2.6 Tofogliflozin2.7 Ertugliflozin2.8 Sotagliflozin2.9 Licogliflozin2.10 Remogliflozin2.11 Henagliflozin2.12 Bexagliflozin2.13 Janagliflozin2.14 Velagliflozin2.15 Sergliflozin Etabonate2.16 Enavogliflozin3 Conclusion
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
