Synthetic Approaches on the Pluramycin-Class Antibiotics

Abstract

The pluramycins constitute a group of antibiotics sharing C-glycosylated anthrapyranone skeleton. Their significant bioactivities and intriguing chemical structures attracted synthetic chemists, and many challenges have been performed toward the total synthesis. This chapter focuses on the synthetic approaches on the pluramycins. The Introduction describes the historical background, structural features, and synthetic problems. In the second section, the synthetic approaches to the aglycons are summarized. The methods for the preparation of the rare deoxyamino sugars are overviewed in the third section. Finally, the synthetic studies toward the C-glycosyl tetracyclic skeletons and the completed total syntheses are described.