Abstract
Benzimidazole is considered a privileged moiety for the development of molecules with therapeutic potential. Over the years several drugs viz: albendazole, pantoprazole, astemizole, telmisartan, thiabendazole, and benomyl have been developed by optimizing benzimidazole-based structures. Given the various pharmacological implications of benzimidazoles, it encourages to explore new synthetic protocols for benzimidazoles. The review presented here highlights exclusively the recent synthetic approaches to prepare benzimidazole derivatives. Numerous search engines like Science Direct, Semantic Scholar, Scopus, PubMed, and Google Scholar were utilized to collect the data. It was found that benzimidazoles were synthesized in an eco-friendly manner by employing a green reaction medium or reagent with improved yields and efficiency. Various precursors such as o-phenylene diamines, 2-nitroaniline, aniline, o-anilinic amidines, and o-aminoaryl ketone were utilized to obtain the benzimidazole. This work will provide support to synthesize numerous benzimidazole compounds in a convenient and eco-friendly manner.
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