Abstract
AbstractAn efficient and concise stereoselective synthesis towards the antimalarial (−)‐Gomphostenin, starting with the enantiomerically pure Wieland–Miescher ketone, is reported. The key transformations of the convergent synthesis involved a stereoselective reductive allylation, Palladium‐catalyzed Saegusa–Ito oxidation, Babler–Dauben oxidative rearrangement, and Wittig olefination reactions. The structure and absolute stereochemistry were determined by X‐ray analysis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.