Abstract
Recently, hypervalent iodine reagents have been used extensively in organic synthesis. In particular, (diacyloxyiodo)benzenes such as phenyliodine(III) diacetate (PIDA) and phenyliodine(III) bis(trifluoroacetate) (PIFA) have received a great deal of attention due to low toxicity, ready availability, easy handling, and reactivities similar to that of heavy metal reagents and anodic oxidation. A variety of available reactions for natural product syntheses have been developed using PIDA, PIFA, and other iodine(III or V) reagents. These reactions are expected to be utilized for pharmaceutical and agrochemical process due to their safety, mild reaction conditions and high yields. This review focuses on recent progress in the use of hypervalent iodine reagents toward total syntheses of various biologically active natural products involving quinones, alkaloids, flavonoids, sugars, and other antibiotics.
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