Abstract

Addition of several organocerium compounds to chiral 1-aminoalkyl chloromethyl ketones 1 affords, after deprotection, enantiomerically pure 3-azetidinols 5. The synthesis of enantiopure amino epoxides 8 is also described by successive treatment of chiral α-amino ketones 1 with organocerium compounds and methyllithium.

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