Abstract

Novel derivatives of acyl-homoserine lactone (AHL) antagonists that target two different types of quorum-sensing (QS) receptors in two very different bacteria have the potential to fend off a diverse group of bacterial pathogens, according to Bonnie Bassler of Princeton University in Princeton, N.J., and her collaborators there and at Ithaca College in Ithaca, N.Y. Efforts to develop QS antagonists are part of a broader strategy to curb bacterial infections with something other than conventional antibiotics, says Bassler, who spoke at a conference convened by the New York Academy of Sciences (NYAS) last April.

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