SYNTHETIC ACCESS TO 2-PYRIDONE SCAFFOLDS

Abstract

In last few decades synthetic organic chemists shows immense interest on the synthesis and functionalization of the 2-pyridone moiety, which is found in many natural compounds. 2-pyridone-containing compounds have shown anticancer and antiviral action. 2-pyridone derivatives are also important building blocks in both the pharmaceutical and material sciences industries. Although several techniques for synthesis of 2-pyridones are known, new methods for more efficient synthesis of 2-pyridones are being developed. Several methods involving Lewis acids or Bronsted acids as catalysts have been developed in recent decades, and annulation of pyridine derivatives with electrophiles has emerged as a valuable strategy to access a diverse array of 2-pyridone derivatives enabling the incorporation of diverse functional groups and stereochemistry. Furthermore, transition metal-catalysed reactions, including C-H activation and cross-coupling activities, have been used to synthesise 2-pyridone scaffolds. These transitions enable late-stage diversification of existing compounds, simplifying synthesis and allowing the production of complex 2-pyridone derivatives. Overall, the development of efficient and diverse synthetic techniques has facilitated quick access to 2-pyridone scaffolds, allowing for their inclusion into drug discovery efforts and usefulness in a variety of organic synthesis applications. Continued progress in this sector bodes well for the identification of new bioactive chemicals and the extension of chemical space.