Abstract
This research was conducted to develop a novel adsorbent based on hyperbranched polyester dendrimers for selective determination and separation of donepezil hydrochloride. In this paper, different generations of hyperbranched polyester dendrimers were grafted onto graphene oxide. New types of carboxyl-terminated hyperbranched polyesters with aromatic-aliphatic structure were synthesized using the direct esterification reaction between succinic acid and phloroglucinol in the presence of p-toluene sulfonic acid catalysts. The 5th generation of polyester dendrimers was modified by p-aminohippuric acid to enhance its adsorption capacity and improve dendrimer biocompatibility. The hyperbranched polyester dendrimers with magnetic nanoparticles were obtained through vacuum freeze-drying process and was used in a new method for the preparation of three-dimensional/ graphene oxide-grafted hyperbranched polyester dendrimers. The synthesized nanoparticles were investigated using Fourier-transform infrared spectrometry, X-ray diffraction, field-emission scanning electron microscopy equipped with energy-dispersive spectroscopy, transmission electron microscopy, Brunauer-Emmett-Teller, thermal gravimetric analysis and vibrating sample magnetometry. The effective experimental parameters were optimized. Adsorption of donepezil hydrochloride by nanoadsorbent can be best described by a Langmuir isotherm with a high correlation coefficient. The three-dimensional/ graphene oxide -grafted hyperbranched polyester dendrimers were applied for extraction of donepezil hydrochloride from biological and pharmaceutical samples through high-performance liquid chromatography-ultraviolet technique.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
