Abstract
AbstractTwo novel 1,2,4‐triazole‐based copper(II) complexes have been synthesized and structurally characterized by X‐ray crystallography: [Cu2LCl3]·0.5[CuCl4]·EtOH (1) and [Cu2LBr3]·Br·H2O (2) (L = 3,5‐bis{[bis(2‐methoxyethyl)amino]methyl}‐4H‐1,2,4‐triazol‐4‐amine). Single‐crystal diffraction reveals that the two Cu atoms have a distorted octahedral geometry for 2, but one Cu atom is in a distorted square‐pyramidal environment and the other one is in a distorted octahedral environment for 1 because of the different bridged halogen atoms. The interactions of the two complexes with calf thymus DNA (CT‐DNA) have been investigated by UV absorption, fluorescence spectroscopy, circular dichroism spectroscopy, viscosity measurements and cyclic voltammetry. The apparent binding constant (Kapp) values for complexes 1 and 2 are 2.98 × 106 and 4.05 × 106 M–1. Furthermore, both the compounds display efficient oxidative cleavage of supercoiled DNA in the presence of external agents. The rate constants for the conversions of supercoiled to nicked DNA are 4.38 × 10–4 s–1 (for 1) and 5.26 × 10–4 s–1 (for 2). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2010)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
