Abstract
A novel Ag(I) citrate complex with ethyl-3-quinolate (Et3qu) was synthesized. Its structure was confirmed using X-ray single crystal to be [Ag(Et3qu)2(citrate)]. It crystallized in the Triclinic crystal system and P-1 space group with unit cell parameters of a = 8.6475(2) Å, b = 11.4426(3) Å, c = 15.2256(3) Å, α = 73.636(2)°, β = 79.692(2)° and γ = 86.832(2)°, while the unit cell volume was 1422.19(6) Å3. In the unit cell, there are two [Ag(Et3qu)2(citrate)] molecules and one unit as the asymmetric formula. The molecular structure comprised one Ag(I) coordinated with two Et3qu molecules via two almost equidistant Ag-N bonds and one citrate ion acting as a mono-negative monodentate ligand via a short Ag-O bond (2.5401(14) Å). Hence, Ag(I) is tri-coordinated and has a highly distorted triangular planar coordination geometry which is more like to be described as a slightly distorted T-shape. The supramolecular structure of the [Ag(Et3qu)2(citrate)] complex was analyzed using Hirshfeld calculations. The H···H (39.3–40.1%), O···H (33.2-34.0%), C···C (9.1–9.5%) and C···H (7.2–7.4%) contacts shared significantly in the packing of the studied Ag(I) complex. The antimicrobial and anticancer activities of the Ag(I) complex were investigated. The [Ag(Et3qu)2(citrate)] complex has broad-spectrum antimicrobial activity specifically against the fungus A. fumigatus. In addition, the IC50 values of 1.87 ± 0.09 µg/mL and 0.95 ± 0.06 µg/mL against the breast MCF-7 and lung A-549 cell lines, respectively, revealed the potent anticancer activity of the [Ag(Et3qu)2(citrate)] complex compared to the free Et3qu (IC50 = 30.64 ± 1.98 and 22.89 ± 1.48 µg/mL, respectively).
Highlights
Silver(I) complexes have gotten a lot of attention because of their pharmacological and biological characteristics, which makes them promising antibacterial and antifungal agents [1–4]
To avoid the drawbacks of cisplatin, researchers have looked into a new class of metal-based drugs that are less poisonous and more efficient in chemotherapy for inhibiting the growth of human tumor cell lines, as well as harmful microbes
The results indicated that both compounds showed inhibitory activity against both cell lines, where the Ag(I) complex has promising anticancer activity
Summary
Silver(I) complexes have gotten a lot of attention because of their pharmacological and biological characteristics, which makes them promising antibacterial and antifungal agents [1–4]. As well as its derivatives, has been the most widely applied metalbased drug in cancer treatment. Their mechanisms of action are recognized by their interactions with DNA. Their use is restricted due to potential side effects, toxicity, and acquired drug resistance [5,6]. To avoid the drawbacks of cisplatin, researchers have looked into a new class of metal-based drugs that are less poisonous and more efficient in chemotherapy for inhibiting the growth of human tumor cell lines, as well as harmful microbes. A set of literature reviews discussed silver(I) complexes with various types of ligands, including amino acids, nitrogen, carboxylic acids, sulfur or phosphorus donor ligands, that have specific effects against a range of various tumor cells [7–9]
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