Abstract
Objective: Our main scope and objectives are to prepare aminoguanidinium salts of amino acids and to characterize them using analytical, IR, and thermal studies, to study the mode of thermal decomposition of aminoguanidinium salts, and to characterize the antioxidants behavior of aminoguanidinium salts.
 Methods: Elemental analysis for C, H, and N was performed on a Vario ELIII elemental analyzer. The IR spectra were recorded on a JASCO-4100 spectrophotometer as KBr pellets in the range of 400–4000 cm-1. The simultaneous TG-DTA studies were under taken on a PerkinElmer SII thermal analyzer and the curves obtained in air using platinum cups as holders with ~ 3 mg of the samples at the heating rate of 10°C/min. The antioxidant capacities of different salts were estimated according to the literature procedure.
 Results: Aspartic acid forms bis-aminoguanidinium salt, whereas glutamic acid forms both mono- and bis-aminogunidinium salts. The IR spectral data of the aminogunidinium salts of aforesaid acids show N-N stretching frequencies in the region 1110–1202 cm-1 revealing the presence of aminoguanidinium moiety.
 Conclusion: The antioxidant properties of these salts were studied using ferric reducing antioxidant power and phosphomolybdenum assay. Results showed significant ferric reducing power which indicated the hydrogen-donating ability of the extract.
Highlights
There has been a surge in research on the potential role of antioxidants in the treatment of atherosclerosis, heart failure, liver dysfunction, neurodegenerative disorders, cancer, and diabetes mellitus
The compositions of the salts were fixed by estimating hydrazine moiety in aminoguanidine and the structural abstract is depicted in Scheme 1
The N-N stretching frequency has been observed around 1100 cm-1 which confirms the presence of aminoguanidine moiety
Summary
There has been a surge in research on the potential role of antioxidants in the treatment of atherosclerosis, heart failure, liver dysfunction, neurodegenerative disorders, cancer, and diabetes mellitus. The main characteristic of an antioxidant is its ability to trap free radicals. Antioxidants provide protection to living organisms from damage caused by uncontrolled production of ROS and concomitant lipid peroxidation, protein damage, and DNA stand breaking. Antioxidant action involves suppressing the formation of ROS, scavenging the free radicals, and reducing agents and quenchers of singlet oxygen formation. The use of synthetic antioxidants must be under strict regulation due to potential health hazards. The search for new antioxidants as alternatives is, of great interest among researchers
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