Abstract
Two cobalt complexes [Co2(L)(phen)(Ac)(PLC)] (1), [Co3(HL)4(CH3O)2(H2O)2] (2) and one zinc complex [Zn2(L)(phen)(Ac)(PLC)] (3), (L = (2-carboxylato-5-(trifluoromethyl)phenyl) (3-hydroxy-4-methoxyphenoxy)amide, phen = 1,10-phenanthroline, Ac = acetate, PLC = 2-amino-4-trifluoromethylbenzoate) have been synthesized and characterized by physicochemical and spectroscopic methods. In addition, X-ray crystallography shows that the Co and Zn atoms in each complex are penta- or six-coordinated, adopting a twisted square pyramid or triangular bi-conical geometry. The antitumor activity of complex against A549 (human lung cancer cells) and Hela (human cervical cancer cells) was screened. Results show that 3 exhibits the most effective antitumor activity (IC50 = 1.369–2.129 μM). Antimicrobial studies also show that 3 exhibits the highest activity.
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