Synthesis, structure, spectroscopic studies and cytotoxic effect of novel palladium(II) complexes with 2-formylpyridine-4-Nethyl-thiosemicarbazone: Potential antitumour agents

Abstract

New palladium(II) complexes have been synthesized by the reaction of Pd(II) with 2-formylpyridine-4-Nethyl-thiosemicarbazone, HFo4NEt, 1. The complexes [Pd(Fo4NEt)Cl], 2, [Pd(H2Fo4NEt)(Fo4NEt)Cl2], 3 and [Pd(Fo4NEt)2], 4 have been characterised by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pd(H2Fo4NEt)(Fo4NEt)Cl2], 3 and the protonated ligand [(H2Fo4NEt)Cl], 5 have been solved by single-crystal X-ray diffraction. The cytotoxic activities of 1–4 have been evaluated for antiproliferative activity in vitro against the cells of three human cancer cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A-549 (non-small cell lung carcinoma) and a mouse L-929 (a fibroblast-like cell line cloned from strain L). The compound 3 display IC50 values in a μM range better than that of the antitumor drug cis-platin against MCF-7 and T-24 cell lines and is considered as agent with potential antitumor activity candidates for further stages of screening in vitro and/or in vivo.