Abstract
AbstractNine bisabolangelone reduction derivatives were synthesized and separated as potential anti‐ulcer agent. Their structures were characterized by 2D NMR, IR, ESI‐MS, elemental analysis and single‐crystal X‐ray diffraction analysis. Preliminarily H+/K+‐ATPase activity evaluation indicated that all the target compounds had a certain inhibitory effect, and compounds II and IV exhibited the better inhibitory activity against H+/K+‐ATPase than bisabolangelone and the commercial omeprazole with the IC50 of 23.21 and 65.32 μmol/L, respectively. The initial structure‐activity analysis suggested that the presence of carbonyl group in six‐membered ring and double bond in side‐chain seemed to be necessary to the activity.
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