Abstract
Two series of platinum(II) complexes of the formula [PtCl2(Meug)(Amine)] (1–6, Meug: methyleugenol) and [PtCl(Meug-1H)(Amine)] (7–13, Meug-1H: deprotonated methyleugenol) were synthesized and characterized by elemental analyses, IR, 1H NMR, 13C NMR, NOESY and XRD spectra. In complexes 1–6 the methyleugenol ligand coordinates to Pt(II) through the ethylenic double bond of the allyl group, and the amine is in the trans-position in comparison to the ethylenic double bond. In complexes 7–13 the chelating methyleugenol ligand is bound to Pt(II) both through the ethylenic double bond of the allyl group and via an aromatic carbon. NOESY spectra and single-crystal X-ray diffraction of [PtCl(Meug-1H)(o-toluidine)] (14) indicate that in 7–14 the amines are in a cis-position with respect to the ethylenic double bond. [PtCl2(Meug)(Pyridine)] (4), [PtCl2(Meug)(Quinoline)] (5) and [PtCl(Meug-1H)(Quinoline)] (9) exhibit strong activities on human cancer cells KB with IC50 values of 3.7, 3.4 and 3.2μg/mL respectively.
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