Abstract
2-Formylpyridine semicarbazone L reacts with cobalt, nickel, copper and zinc chlorides, nitrates and perchlorites to form coordination compounds of compositions ML2X2·nH2O (M=Co, Ni, Cu, Zn; X = Cl, NO3, ClO4; L = NC5H4-CH=N-NH-C(O)-NH2; n = 0, 1) and CuLX2·nH2O (X = Cl, Br, NO3; n = 0−0.5). Complex CuL(NO3)2 has polynuclear, CuLX2·0.5H2O (X = Cl, Br), binuclear, and other compounds, mononuclear structures. Azomethine L behaves in them as tridental N,N,O-ligand. Thermolysis of these complexes proceeds through such stages as dehydration (80–95°C), deactivation (145–155°C) and complete theral degradation (170–590°C). Complexes CuLX2·nH2O (X = Cl, NO3; n = 0−0.5) were established to inhibit in vitro the growth and reproduction of 100% of cancer cells of human mieloid leukaemia HL-60 at 10−4 M concentration. At 10−5 M concentration they inhibit only 10% of cells, and at 10−6 M concentration they do not possess anticancer activity.
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