Abstract
A 14 nuclear silver(I) ferrocenylacetylide cluster (X1), Ag14(CCFe)12(CH3CN)4(OH)2, was synthesized from the starting material of ethynylferrocene and soluble silver salt. It was characterized by infrared spectroscopy (IR), elemental analysis (EA), powder X-ray diffraction analysis (XRD) and X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA) and ultraviolet-visible spectrum (UV–Vis). The interaction of X1 with DNA was investigated by UV–visible spectroscopy and electrochemical methods, and the result showed that X1 bind with DNA at the groove in an electrostatic manner. The result of molecular docking showed that X1 might interact with ct-DNA at either small or large groove, and that X1 had strong binding affinity with colon cancer (3ig7) and breast cancer (1hk7) receptor proteins. X1 might find application in the treatment of cancer diseases, providing a new direction for pharmacological research.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
