Abstract
The interaction of dimethyl- and diethyltin(IV) cations with methylpyridoxine iodide ([MePN]I; PN = pyridoxine) was studied in ethanol/water (80:20(v/v) containing Cl −, NO 3 − or I − ions in different molar ratios. Several compounds containing the deprotonated (MePN-H) or neutral (MePN) ligand were isolated and characterized by elemental analysis, IR and NMR ( 1H, 13C, 119Sn) spectroscopy and FAB mass spectrometry. The compounds [SnMe 2(MePN-H)](I 3), [SnEt 2(MePN-H)](I 3), [SnMe 2(MePN-H)(NO 3)], [SnEt 2(MePN-H)(NO 3)] and [SnMe 2(MePN) 2]I 2 were studied by X-ray diffractometry. The compounds in which the MePN-H ligand is present can be described as containing dinuclear [SnR 2(MePN-H)] 2 2+ (R = Me, Et) units, in which two bridging chelating methylpyridoxinato ligands link two metal atoms. Interactions also exist between the metal and the I 3 − or NO 3 − anions and these interactions differ in degree and type. On the other hand, in the only example of a complex containing the MePN ligand, the mononuclear [SnMe 2(MePN) 2] 2+ unit is present. The in vitro antitumor activity of these complexes against the HeLa, A2780 and A2780cis cell lines was determined and compared with that of the equivalent PN derivatives.
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