Synthesis, structure and cytotoxic activity of platinum(II) dimers with bridging imidate ligands in head-to-head arrangement

Abstract

The cis-diammineplatinum(II) head-to-head dimer complexes with imidate ligands, [Pt 2(NH 3) 4(SI) 2](NO 3) 2 · H 2O, [Pt 2(NH 3) 4-(EMGI) 2] (NO 3) 2 and [Pt 2(NH 3) 4(DMGI) 2](NO 3) 2 (where SI = succinimidate, EMGI = 3-ethyl-3-methylglutarimidate and DMGI = 3,3-dimethylglutarimidate), are prepared from aqueous solutions of platinum(II) in the presence of the corresponding imides. These complexes form a pair of dimers within the crystals stabilized by hydrogen bonds as shown by X-ray structural analyss. They exhibit high antitumor activities against S180 and L1210 cancer cell lines.