Abstract
Four new diethyltin N‐[(2‐oxyphenyl)methylene]phenylalaninates, (CH3CH2)2Sn[2‐O‐3‐X‐5‐YC6H2CHNCH(CH2Ph)COO] (X, Y = H, H, 1; H, Br, 2; H, OCH3, 3; Br, Br, 4), have been synthesized and characterized using elemental analysis and infrared and NMR (1H, 13C and 119Sn) spectra. The crystal structures of 1, 2, 3, 4 have been determined. Compounds 1 and 2 have a 12‐membered macrocyclic structure with a trimeric [Sn3O6C3] core. Each tin atom is six‐coordinated in distorted [SnC2NO3] octahedral geometry. Compound 3 is a centrosymmetric weak dimer in which the two tin centers are linked by two asymmetric SnO⋅⋅⋅Sn bridges involving the phenolic oxygen of the ligand and two Sn⋅⋅⋅O interactions from ether oxygen of the adjacent ligand. The coordination geometry of the tin atom can be described as a distorted pentagonal bipyramid with two ethyl groups in axial positions. Compound 4 is a novel binuclear tin complex, formed by the carboxylate of a ligand asymmetrically bridging two tin atoms, which contains a five‐coordinated tin and a six‐coordinated tin. Bioassay results have shown that the compounds have weak in vitro activity against two human tumor cell lines, A549 and CoLo205. Copyright © 2016 John Wiley & Sons, Ltd.
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