Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231)

Abstract

This study examines the new synthesis of Pt (IV) and Au (III) Mannich base complexes derived from ciprofloxacin. The complexes were then used as precursors to prepare SiO2/PtO2 and SiO2/Au2O3 nanoparticles by depositing the synthesized complexes on porous silica nanoparticles. Elemental analysis, FT-IR, UV-vis, molar conductivity measurements, and melting point were used to characterize this ligand and its metal complexes. Elemental analysis data show that the general formula of the metal complexes formed is [M(L)2Cl2] nCl.H2O, where L = Mannich base ligand and M = Au(III) and Pt(IV), and n = 1,2 respectively with octahedral structure. The chemical structure and morphology of the metal oxide nanoparticles are investigated using FT-IR, XRD, AFM, TEM, and SEM. In the next step, the ligand and its complexes, SiO2/PtO2 and SiO2/Au2O3 nanoparticles were examined to investigate their toxicity (in vitro) as an anticancer agent to MDA-MB-231 cell lines by using different concentrations (50, 100, 200, and 400 µg /mL). Based on the results obtained from the cytotoxic activity, it can be concluded that the synthesized compounds are promising as new cancer candidates in the future, especially in high concentrations