Abstract
The interaction of selected biometals with dinitrogen donor ligand, 1,10-phennathroline (phen) and amino acid, 2-amino-4-(methylthio)butanoic acid (methionine; met) resulted in isolation of three mononuclear complexes. The prepared complexes were characterized by diverse techniques including elemental and spectroscopic analysis. From the analytical and spectral data, octahedral geometry was proposed to the synthesized metal (II) complexes. Bonding of the metal ion through N- and O- donor atoms of the ligands is revealed by infrared studies. The compounds showed moderate solubility in distilled water and in some common organic solvents. In vivo evaluation of the antimicrobial activities of the metal complexes showed improved inhibitory activity against some micro-organisms as compared to the ligands, with Co(II) and Cu(II) complexes showing the highest activities against the fungi.
Highlights
Drug resistance, especially antibiotics, is one of the most important threats to public health
2-amino-4-(methylthio)butanoic acid was purchased from Loba Chemie Pvt Ltd, analytical grade purity, while Mn (II), Cu (II) and Co (II) chlorides, 1,10-phenanthroline, dimethylsulfoxide, ethanol, and methanol, Muller Hinton agar, Nutrient agar were purchased from Acros and Merck Laboratories, analytical grade purity
The absorption bands between 200 and 400 nm were observed for the organic part of the complexes and that of > 400 nm was due to the metal ion
Summary
Especially antibiotics, is one of the most important threats to public health. Considering the swift spread of multi-drug resistance, the design and development of new antimicrobial agents which act on newly adapted microorganisms has become a priority. Metal-based drugs play an important role in medicine for the treatment of various diseases. Modern medicinal chemistry seeks to intentionally investigate the structure and properties of metal complexes for medicinal function has developed immensely. This class of molecules have been found throughout the life science and vary tremendously in their function and complexity. These compounds play an essential part of metabolism and cellular signaling and as a part of drugs (Ozturk et al, 2014). The knowledge gained from this study should be useful for the development of potentially new therapeutic agents for combating antibiotic resistance
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