Abstract
Carboxylate functionalized ligand (LH) was synthesized as a result of reaction between maleic anhydride and 2�aminothiazole. This ligand was further reacted with Co(II), Ni(II), Cu(II), Zn(II) and Bi(III) ions to yield respective metal complexes. The structural aspects were studied using FTIR, UV�Visible and 1H-NMR spectroscopy. Non-electrolytic behavior was revealed by the conductivity measurements. Except Bi(III) being octahedral, all other complexes prepared are tetrahedral in geometry. Ligand (LH) and its metal complexes were also investigated for their in vitro antibacterial and antifungal activities. All the complexes exhibited significant antibacterial activity but non-significant antifungal activity.
Highlights
An important heterocyclic compound thiazole, is biologically active in many drug structures,for exampleritonavir [1], nitazoxanide [2], nizatidine [3], etc
Considering structure and biological significance of 2-aminothiazole, its reaction with maleic anhydride was carried out to produce ligand(LH), which was further reacted with Co(II), Ni(II), Cu(II), Zn(II) and Bi(III) ions to yield respective metal complexes, whose structural, antibacterial and antifungalactivities are part of this manuscript
The ligand (LH) and its metal complexes were synthesized as outlined in Schemes 1 and 2
Summary
An important heterocyclic compound thiazole, is biologically active in many drug structures,for exampleritonavir (anti-HIV drug) [1], nitazoxanide (antiparasitic agent) [2], nizatidine (antiulcer agent) [3], etc. Considering structure and biological significance of 2-aminothiazole, its reaction with maleic anhydride was carried out to produce ligand(LH), which was further reacted with Co(II), Ni(II), Cu(II), Zn(II) and Bi(III) ions to yield respective metal complexes, whose structural, antibacterial and antifungalactivities are part of this manuscript. 2.Materials and methods 2-Aminothiazole (Sigma Aldrich), acetic acid, maleic anhydride (M and B Chem.), methanol, CoCl2.6H2O(Uni Chem.), NiCl2.6H2O (United Lab.),CuCl2.2H2O (Fluka Chemika), ZnCl2 (Riedel-de-Haen), BiCl3 (Beijing Chem.), were purchased and used as such. Were separately dissolved in glacial acetic acid (10 mL). Both the solutions were mixed and made to stir overnight at 25oC. Precipitation of pale yellow color occurred and was filtered, washed with glacial acetic acid, n-pentane and subsequently dried for further use. Fungal stains i.eCandida albicans, Trichphyton rubrum, Aspergillus niger, Microsporum canis, Fusarium liniwere used to find anti-fungal potential of the ligand (LH) and its complexes by agar tube dilution protocol
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