Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base-Ru(ii)-curcumin organometallic conjugate.

Sankarasekaran Shanmugaraju,Sandra Estalayo-Adrián,Chris S Hawes,Graeme W Watson,Deivasigamani Umadevi,Thorfinnur Gunnlaugsson,Tobi Arisa,Hannah L Dalton,Bjørn La Cour Poulsen,Aramballi J Savyasachi,D Clive Williams

doi:10.1039/c8cc01584h

Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base-Ru(ii)-curcumin organometallic conjugate.

Sankarasekaran Shanmugaraju, Sandra Estalayo-Adrián + Show 9 more

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https://doi.org/10.1039/c8cc01584h

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Journal: Journal of the Chemical Society Chemical Communications	Publication Date: Jan 1, 2018
Citations: 35	License type: other-oa

Affiliation: Trinity College Dublin

#Curcumin Conjugate #Biological Investigation

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Abstract

The synthesis, photophysics and biological investigation of fluorescent 4-amino-1,8-naphthalimide Tröger's bases (TB-1-TB-3) and a new Tröger's base p-cymene-Ru(ii)-curcumin organometallic conjugate (TB-Ru-Cur) are described; these compounds showed fast cellular uptake and displayed good luminescence and cytotoxicity against cervical cancer cells.

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