Abstract
In this work, a borosilicate glass sample (5SiO2–45B2O3–20Na2O–25CaO–5Ag2O) was added to nano-sized carbonated hydroxyapatite (CHA) powders with different contents up to 20 wt% to improve the bioactivity, antibacterial effect, physical and mechanical properties of the resulting nanocomposites. The CHA and BG nanocomposite powders were mixed, milled with a high-energy ball mill, then pressed into pellets under hydraulic pressure, and finally sintered in muffle at 650 ºC. Subsequently, the sintered samples were subjected to X-ray diffraction (XRD) technique, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) to examine their structure, chemical composition and microstructure, respectively. Furthermore, the physical and mechanical properties of the sintered nanocomposites were also measured. Moreover, the in vitro bioactivity of the prepared nanocomposites was tested after being soaked in a simulated body fluid (SBF) solution for 10 days and their surfaces were then examined with XRD and SEM. In addition, the antibacterial behavior of these samples was tested against E. coli and S. aureus by the disc-diffusion method. The results obtained indicated that the sample with the highest BG content possessed the best bioactivity, antibacterial effect, physical and mechanical properties. Based on these results, the prepared nanocomposites can be used in various biomedical applications.
Highlights
As a result of the enormous improvements in medicine, the life span of people around the world has been increased, forcing researchers to constantly develop new prostheses for use in bone repair purposes [1]
In response to these facts, scientists believe that bioactive materials including some calcium phosphate (Ca-P) compounds and bioactive glasses could be greatly useful for achieving this goal [3]
It is evident from this figure that successive increases in bioactive glasses (BGs) content lead to noticed increases in bulk density
Summary
As a result of the enormous improvements in medicine, the life span of people around the world has been increased, forcing researchers to constantly develop new prostheses for use in bone repair purposes [1]. In this context, many biomaterials are used to achieve this goal including various metals and their alloys, bioactive glasses, glass-ceramics, calcium phosphates and calcium silicates. It is worth to note that these attractive characteristics are closely related to the surface properties of the implant [2] In response to these facts, scientists believe that bioactive materials including some calcium phosphate (Ca-P) compounds and bioactive glasses could be greatly useful for achieving this goal [3]
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