Abstract
New bidentate or tridentate Schiff bases and their VO(II) and Co(II) complexes formed by the condensation of methyl isobutyl ketone with nicotinamide (mna)/2-amino-4-chlorophenol (map) and 2-hydroxy acetophenone with nicotinamide (han)/isoniazide (hai). Physicochemical characterization has been carried out to determine the structure of the complexes. The FAB mass and thermal data show degradation pattern of the complexes. XRD analysis reveals that all the studied complexes crystallize as tetragonal crystal system. Some of the complexes have been screened for their antimicrobial activity by the well diffusion technique using DMSO as solvent on different species of pathogenic bacteria/fungi, that is, E. coli, S. aureus, S. fecalis, A. niger, T. polysporum, and their antimicrobial potency have been discussed. It has been found that all the complexes are antimicrobially active and show higher activity than the free ligand. Metal chelation affects significantly the antimicrobial/bioactive behavior of the organic ligands.
Highlights
Research interest in V/O chemistry derives from its utility in several biological and industrial processes [1]
Vanadium-containing compounds have their utility as insulin mimetic and antiamoebic agent
It is suggested that vanadium could be considered as a representative of a new class of nonplatinum metal antitumor agents. Schiff bases and their complexes have a variety of applications in biological clinical and analytical fields [5]
Summary
Research interest in V/O chemistry derives from its utility in several biological and industrial processes [1]. Vanadium-containing compounds have their utility as insulin mimetic and antiamoebic agent. It is suggested that vanadium could be considered as a representative of a new class of nonplatinum metal antitumor agents. Schiff bases and their complexes have a variety of applications in biological clinical and analytical fields [5]. There has been a considerable interest in the chemistry of hydrazine and hydrazone compounds because of their potential pharmacological applications [6]. The coordination compounds of aroylhydrazones have been reported to act as enzyme inhibitors and are useful due to their pharmacological applications [7]. We describe the synthesis, characterization, and biological activity of some oxovanadium (IV) and cobalt (II) complexes of Schiff bases, namely, mna, map, han, and hai
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