Abstract
Originating from the xanthine derivatives, a class of potent dipeptidyl peptidase IV (DPP-4) inhibitors for the treatment of type 2 diabetes have been discovered. These inhibitors play a vital role in maintaining the levels of endogenous GLP-1. In this study, Xanthine-Quinazoline derivatives have been designed and synthesized. R- and S-isomers of the target compound were separated by chiral column chromatography and the relative configurations were studied by means of NMR (nuclear magnetic resonance), ECD (electronic circular dichroism), FT-IR (fourier transform infrared spectroscopy), and DFT (density functional theory) calculations. In addition, the absolute configurations (ACs) of the title compound were confirmed by ECD, PES (Potential Energy Surface), optical rotation (OR), and theoretical calculations.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
