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Abstract
The Preparation of 9-Methyl-3-thiophen-2-yl-thieno [3, 2-e] [1, 2, 4] triazolo [4, 3-c] pyrimi-dine-8-carboxylic acid ethyl ester is described. Elemental analysis, IR spectrum, 1H NMR, 13C NMR and X-ray crystal structure analyses were carried out to determine the composition and molecular structure of the title compound. There are two independent molecules in the asymmetric unit exhibiting intermolecular C-H…N, C-H…O interactions with additional π-π interaction that further helps in stabilizing the supramolecular structure. The results showed that the proposed method for synthesis is simple, precise and accurate which was further confirmed by crystal structure analysis.
Highlights
Pyrimidine and thienopyrimidine derivatives are found in a variety of natural products, agrochemicals and veterinary products [1,2]
The results showed that the proposed method for synthesis is simple, precise and accurate which was further confirmed by crystal structure analysis
The compound was subjected to single crystal X-ray diffraction analysis so that its supramolecular structure could be investigated in terms of possible intermolecular interactions
Summary
Pyrimidine and thienopyrimidine derivatives are found in a variety of natural products (viz., purines, pyrrolopyrimidines, pyridopyrimidines, pteridines), agrochemicals and veterinary products [1,2]. Compounds containing fused pyrimidine ring make up a broad class of heterocycles that has attracted attention in the past few years owing to its wide range of biological activities such as anticancer [3], antiviral [4], antitumor [5] and anti-inflammatory activities [6]. The rapid growth in the literature dealing with the synthesis and biological activity of the thienopyrimidine derivatives [7] prompted us to undertake the synthesis of novel fused thienopyridine derivative. The synthesis of the compound was followed by measurement of the analytical data and subsequent spectroscopic analysis using IR, 1H-NMR and 13C-NMR techniques to confirm the presence of the supposed ring system. The compound was subjected to single crystal X-ray diffraction analysis so that its supramolecular structure could be investigated in terms of possible intermolecular interactions
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