Abstract
AbstractNine 4,5‐dihydro‐1,2,4‐oxadiazoles, 2a‐i, were synthesized by the reaction of benzamidoximes, 1a‐i, with aliphatic and aromatic aldehydes. None of these compounds were encountered in the literature. The ultraviolet, infrared and proton magnetic resonance spectral studies supported the cyclic structure. Structure determination of a chloral‐benzamidoxime adduct, 15, by X‐ray crystallography helped us to suggest the mechanism of formation of 4,5‐dihydro‐1,2,4‐oxadiazole from benzamidoxime and an aldehyde. Substances 2a,b,d,e,g,h, showed some activity against fungus Neurospora crassa. Compound 2e also presented growth inhibition in Mycobacterium smegmatis.
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