Synthesis, spectroscopic investigation and bioactivities of metal complexes from curcuma longa derivative

Abstract

Curcumin and isatin derivatives demonstrated vital role in biological activities. In view of their biological significance, potentially tridentate ligand was synthesized from curcumin derivative and its bivalent manganese, cobalt, nickel, copper and zinc complexes are synthesized and investigated spectrochemical studies based on elemental analysis, IR, Ultraviolet–visible, NMR (1H and 13C) and EPR studies. EPR spectrum of copper(II) system noticed considerable covalent character. Spectroscopic analysis revealed that chelation of ligand and metal ion with deprotonation of enolate oxygen, azomethine nitrogen and carbonyl oxygen. The ligand and crystalline complexes were subjected to powder X-ray diffraction analysis. The emission peaks are noted in the range between ∼500–700 nm wavelengths observed by fluorescence spectroscopy. Samples were tested to antifungal, antibacterial (MIC) and antioxidant activities. Biological results were showed high to moderate activity against various microorganisms. The DNA cleavage ability indicated effective cleavage activity. Compounds have been screened towards human breast cancer (MCF-7) and leukemia (K-562) cell lines. They evidenced potent effect against growth of cancer cell lines compared to the effective anticancer agent Adriamycin. Hence the compounds can be considered to design a promising chemotherapeutic agent and excellent tool for cellular imaging.