Synthesis, spectroscopic characterizations and antimicrobial activity of copper and zinc complexes of levofloxacin, ciprofloxacin and 3-carboxy-4-quinolone

Abstract

Copper and zinc complexes based on levofloxacin, ciprofloxacin and 3-carboxy-4-quinolone with molecular formula [M(C18H19FN3O4)2]·2H2O, [M(C17H17FN3O3)2]·2H2O and [M(C10H6NO3)]·2H2O, respectively, were synthesized by the reaction of copper or zinc nitrate and the corresponding ligand. Complexes were not obtained as single crystals. Infrared spectroscopy, high resolution mass spectrometry and thermogravimetric analysis are also performed. Except in the case of copper complexes, 1H and 13C NMR spectra were obtained. Antimicrobial activity of complexes and their ligands are carried out against a panel of microorganism from ATCC cultures and strains from clinical isolate were also included. All complexes showed moderate to good antimicrobial activity depending on the concentration.