Abstract
Mononuclear chelates of Ni(II), Co(II), Fe(III), Cd(II), and Cu(II) derived from triazole novel tridentate ligands were prepared and characterized by different spectroscopic methods. The metal to ligand ratio was 1 : 2, which was revealed by elemental analysis. All the complexes were electrolytic in nature as suggested by the conductivity measurements. IR pointed out that the coordination of the triazole ligand toward the metal ions was carried out through N amino and S thiophenolic atoms. The complexes were found to have octahedral geometry, and their thermal stability was also studied. The XRD spectrum of Co(II) and Fe(III) complexes concluded their crystalline structure. The parent ligand and its chelates were investigated for antimicrobial potential. Bioassay of all triazole complexes showed increased activity as compared to that of the ligand. The complexes having Ni(II), Co(II), and Cu(II) ions as metal center exhibited superior antibacterial activity in opposition to Gram-positive (B. subtilis and S. pyogenes) and Gram-negative (E. coli and P. vulgaris) bacterium as compared to standard.
Highlights
Mononuclear chelates of Ni(II), Co(II), Fe(III), Cd(II), and Cu(II) derived from triazole novel tridentate ligands were prepared and characterized by different spectroscopic methods. e metal to ligand ratio was 1 : 2, which was revealed by elemental analysis
We find the metal complexes of ligands which have S,N-heterocycles promising for enhanced biological activities compared to the native ligand [9]. e preparation of metal complexes containing
The synthesis of bidentate triazole ligand and its monomeric metal complexes in the company relating to Cd(II), Co(II), Fe(III), Cu(II), and Ni(II) ions is demonstrated. e synthesized complexes were analyzed through state-of-the-art physicochemical techniques including NMR, IR, and EDS and screened for antibacterial potential against some pathogenic species
Summary
Mononuclear chelates of Ni(II), Co(II), Fe(III), Cd(II), and Cu(II) derived from triazole novel tridentate ligands were prepared and characterized by different spectroscopic methods. e metal to ligand ratio was 1 : 2, which was revealed by elemental analysis. Bioassay of all triazole complexes showed increased activity as compared to that of the ligand. Compounds which have cyclic imines are of great importance in forming stable complexes with some transition metal ions [3, 4]. We find the metal complexes of ligands which have S,N-heterocycles promising for enhanced biological activities compared to the native ligand [9]. In recent years, preparing coordination ligands using 1,2,4-triazole moiety acquired great attention [16]. In present study we discuss the preparation, characterization, and antibacterial study relating to Ni(II), Cu(II), Fe(III), Cd(II), and Co(II) complexes of 4-amino-5-stearyl-1,2,4triazole-3-thiol (HL). The synthesis of bidentate triazole ligand and its monomeric metal complexes in the company relating to Cd(II), Co(II), Fe(III), Cu(II), and Ni(II) ions is demonstrated. The synthesis of bidentate triazole ligand and its monomeric metal complexes in the company relating to Cd(II), Co(II), Fe(III), Cu(II), and Ni(II) ions is demonstrated. e synthesized complexes were analyzed through state-of-the-art physicochemical techniques including NMR, IR, and EDS and screened for antibacterial potential against some pathogenic species
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