Synthesis, spectroscopic characterization, antimicrobial activity and crystal structure of [Ag2(C10H10N3O3S)2(C5H5N)3

Abstract

Silver complex of 4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide (sulfamethoxazole) (SMX) has been synthesized and characterized by elemental analysis, infrared, UV and NMR spectroscopy. The title compound, [Ag2(C10H10N3O3S)2(C5H5N)3] crystallizes in the orthorhombic space group Pna21 with lattice parameters a=17.9527(5), b=8.6529(3), c=25.1621(7)Å and Z=4. The structure is solved by direct method and refined to a final R=0.0567 for 6732 reflections with I⩾2σ(I). The results of IR, 1H NMR and 13C NMR spectral data suggest the binding of silver atom to the sulfonamide ligand which is in agreement with the crystal structure determination. X-ray analysis revealed that in the title compound, one silver atom is surrounded by three N atoms and one Ag atom leading to a distorted tetrahedral geometry and another silver atom is surrounded by four N atoms and one Ag atom leading to a slightly distorted square pyramid geometry with Ag⋯Ag separation distance of 3.026Å. The dihedral angle between phenyl and isoxazole ring is 85.7(4)°. In the crystal structure, the molecules are linked via NH⋯O, CH⋯O intermolecular and CH⋯O intramolecular interactions. Silver complex of sulfamethoxazole has been studied by electrical and thermal analysis. Silver sulfamethoxazole presents different antibacterial behavior against Escherichia coli and Staphylococcus aureus strains.