Synthesis, spectroscopic characterization and biocidal activity of some diorganotin(IV) complexes of salicylaldehydethiosemicarbazones and related ligands. Molecular and supramolecular structures of [R2Sn(OArCHNNCSNH2)], where R = Me, Ph and Ar =  C6H4, C6H3(5‐Br) and C6H3(5‐Cl), and of [Me2Sn{OC6H3(5‐Br)CHNNCSNH2}]·OH2

Abstract

AbstractNine diorganotin(IV) compounds of Schiff bases derived from salicylaldehyde/substituted salicylaldehyde and thiosemicarbazide were synthesized. The compounds, with general formulae [R2Sn(OArCHNNCSNH2)], where R = Me, n‐Bu, Ph and Ar =  C6H4, C6H3(5‐Cl), C6H3(5‐Br), were characterized by UV and IR spectroscopy, NMR (1H, 13C and 119Sn) spectroscopy and elemental analysis. X‐ray crystallographic studies of five of these complexes indicate penta‐coordination of tin within a distorted C2NOS trigonal bipyramidal geometry in each case. The crystal packing in four of the structures features {··· NCNH}2 synthons, but in [Ph2Sn(OArCHNNCSNH2)] the {··· SCNH}2 synthon is predominant. The biological activity of these compounds against four fungal pathogens (Curvularia eragrostidis, Alternaria porri, Dreschlerea oryzae and Macrophomina phaseolina) of four different crops (Camellia sineusis, Guizotia abyssinica, Oryzae sativa and Solanum melongena) and some bacteria (Aeromonas hydrophila, Salmonella typhi, Salmonella typhimurium, Salmonella flexnri, Escheria coli, Salmonella aureus, Bacillus subtilis and Lactobacillus rhamnosus) were investigated. Their cytotoxicity was also investigated against several human cancer cell lines. Copyright © 2007 John Wiley & Sons, Ltd.