Synthesis, Spectroscopic Characterization, and Anticancer Activity of Metal Complexes with a Novel Schiff Base Ligand from -Diketone Derivatives

Abstract

A new series complexes of Ni(II), Mn(II), Co(III), Cu(II), Cr(II), Zn(II), Zr(IV), Cd(II), and La(III) prepared by the reaction of the metal salt with a new Schiff base ligand. This Schiff base obtained by the condensation of p-phenylenediamine, 4-chlorobenzaldehyde, and acetyl acetone. The confirmation of the ligand and its metal complexes were characterized by multiple techniques such as, elemental analyses, magnetic susceptibility studies, FTIR 1H, 13C-NMR, XRD, molar conductance, UV-vis spectral analyses, and thermal analyses. The conductivity measurements of the complexes in DMF solutions indicated that the prepared complexes are nonelectrolytes. From the spectral data, an octahedral geometry was suggested for all complexes. The metal complex [(L)2Zr(Cl)2].3H2O showed the highest antifungal activity. The complexes [(L)(HL)Co(Cl)2].3H2O, and [(L)2Cd(H2O)2] showed antibacterial activities higher than the other complexes. All complexes are exhibited potent fungicides and bactericides than the ligand. Complex [(L)2Cd(H2O)2] exhibited considerable cytotoxicity against PC-3, SKOV3, and HeLa cells. The ligand C18H17N2OCl (HL) showed strong toxicity towards PC-3, HeLa cells, and moderate toxicity against SKOV3 cells.