Synthesis, spectroscopic characterization, analgesic, and antimicrobial activities of Co(II), Ni(II), and Cu(II) complexes of 2-[N,N-bis-(3,5-dimethyl-pyrazolyl-1- methyl)]aminothiazole

Abstract

Synthesis of new series of Cu(II), Co(II), and Ni(II) from the ligand 2-[N,N-bis-(3,5-dimethyl-pyrazolyl-1-methyl)]aminothiazole is described. The ligand and its complexes were characterized by various techniques such as elemental analysis, FT-IR, UV–Visible, 1H and 13C NMR spectra, mass spectrum, and conductometry. The electronic absorption spectra and magnetic susceptibility measurements suggest a square planar geometry for Cu(II) complex and distorted tetrahedral geometry for the other metal(II) complexes. The EPR spectrum of Cu(II) complex recorded at 77°K confirms the distorted square planar geometry. The antimicrobial activities of the ligand and metal complexes against the bacterial species such as Xanthomonas maltophilia, Chromobacterium violaceum, Acinetobacter,Staphylococci, Streptococci, and the fungus Candida albicans are carried out and the results indicated that all compounds exhibit more antibacterial activity than the standard drug. The synthesized compounds were investigated for analgesic activity and they act as potent analgesic drugs.