Abstract
The mixed ligand transition metal complexes of 4‐N,N‐dimethylaminopyridine (DP) and chloride as primary and secondary ligands with the general formula [M(DP)3Cl3]; M = Cr(III) and Fe(III); [M′(DP)4Cl2]M′ = Co(II), Ni(II), Cu(II), and Cd(II) were synthesized in a microwave oven. The complexes were characterized by FT‐IR and UV, 1HNMR, 13CNMR spectra, TG/DTG, and various physicoanalytical techniques. From the magnetic moment measurements and the electronic spectral data, a distorted octahedral geometry was proposed for the complexes. The complexes express similar trend of thermal behaviour such that they lose water of hydration initially with the subsequent emission of organic and inorganic fragments and leave left the metal oxides as residue. The activation thermodynamic parameters, such as E*, ΔH*, ΔS*, and ΔG* of the metal complexes, illustrate the spontaneous formation of the complexes. The antimicrobial studies against various pathogenic bacterial and fungal serums insist on that the enhanced potential of the complexes over their ligand and their biopotential properties increases with concentration. The DNA interaction of the synthesized complexes on CT‐DNA was investigated by UV‐Vis spectroscopy, viscosity, thermal denaturation, and electroanalytical experiments and their binding constants (Kb) were also calculated.
Highlights
The search for soluble bioactive compounds of metals that are suitable for nutritional supplementation to humans is a long standing problem and persists to provide enough thrust for the fundamental research
It was concluded from the observations that the complexes have molar conductivity values in the range from 21.9 to 27.7 Ω−1 mol−1 cm2 indicating the nonionic nature of these complexes and were considered as nonelectrolytes
It is understood that the increasing step values of TΔS∗ clearly override the decreasing values of ΔH∗ therein reflecting that the rate of removal of the subsequent species will be lower than that of the preceding one [25]
Summary
The search for soluble bioactive compounds of metals that are suitable for nutritional supplementation to humans is a long standing problem and persists to provide enough thrust for the fundamental research. Metal complexes are useful for the pharmaceutical purposes because of their potential ability to bind DNA via multitude interactions and cleave the duplex by virtue of their reactivity. Understanding of the DNA-metal complexes interactions are driven by few applications, which include therapeutic approaches, nucleic acid conformations, and nanopharmaceuticals. The characterisation of DNA recognition by redox and photoactive studies are substantially aided by studying the DNA cleavage ability of the metal complexes. It is remarkable that the complexes alone were proficient in bringing about the oxidative as well as the rare hydrolytic cleavage of DNA double strand. The present work attempts to look at this aspect on the involvement of transition metal compounds on biomolecules by the antimicrobial and DNA binding and cleavage applications with the participation of the mixed ligand complexes of 4N,N-dimethylaminopyridine and chloride ions with some biologically active metal ions
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