Synthesis, spectroscopic, and biological activities of two binuclear complexes [Cu(II)(1-phenylamidino-O-methylurea)2(H2O)]2(Cl2)2 and [Cu(II)(1-phenylamidino-O-i-butylurea)tmen]2(Cl2)2·2H2O

Abstract

EPR spectra of two copper(II) binuclear complexes, [Cu(II)(1-phenylamidino-O-methylurea)2(H2O)]2(Cl2)2 (1) and [Cu(II)(1-phenylamidino-O-i-butylurea)tmen]2(Cl2)2 · 2H2O (2), at room temperature showed fine structure transitions (ΔM s = ±1) and a very weak half-field signal corresponding to forbidden transitions (ΔM s = ±2). The spectrum of 1 showed disappearance of normal and half-field transitions when cooled to 77 K, suggesting antiferromagnetical coupling dicopper complex which is also supported by the low magnetic moments (µ eff = 1.64 B.M.). The isotropic exchange interaction constant J (41 cm−1) for 2 indicated that interaction between the two spins of the binuclear complex is ferromagnetic, confirmed from the high magnetic moment value (µ eff = 2.25 B.M.). The binding of these complexes with calf thymus DNA suggested that these complexes interact with DNA by electrostatic or groove binding, not by intercalation. The two complexes have good antibacterial activity against tested bacteria responsible for urinary tract infection.