Abstract
A series of metal complexes of Cu(II) and Ni(II) having the general composition with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.
Highlights
The chemistry of thiosemicarbazones has received considerable attention in view of their variable bonding modes, promising biological implications, structural diversity, and ion-sensing ability [1,2,3]
Thiosemicarbazone complexes have been intensively investigated for antiviral, anticancer, antitumoral, antimicrobial, antiamoebic, and antiinflammatory activities
The inhibitory action is attributed due to their chelating properties [6,7,8,9,10,11,12,13,14,15,16]. The activity of these compounds is strongly dependent upon the nature of the heteroatomic ring and the position of attachment to the ring as well as the form of thiosemicarbazone moiety [17]
Summary
The chemistry of thiosemicarbazones has received considerable attention in view of their variable bonding modes, promising biological implications, structural diversity, and ion-sensing ability [1,2,3]. The inhibitory action is attributed due to their chelating properties [6,7,8,9,10,11,12,13,14,15,16] The activity of these compounds is strongly dependent upon the nature of the heteroatomic ring and the position of attachment to the ring as well as the form of thiosemicarbazone moiety [17].
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