Synthesis, spectroscopic and antibacterial studies on bis(cyclopentadienyl)- hafnium(IV) derivatives with dithiocarbamates derived from α-amino acids

Abstract

The reactions of bis(cyclopentadienyl)hafnium(IV) dichloride with novel dithiocarbamate ligands [Na 2 (S 2 C-NH-(R)-COO)], derived from α-amino acids (glycine, leucine, β-alanine and dl-alanine), have been studied in THF/DMF mixture and binuclear complexes of type [{(C 5 H 5 ) 2 HfCl} 2 (S 2 C-NH-(R)-COO)] have been isolated. Tentative structures of the complexes have been proposed on the basis of analyses, electrical conductance, magnetic moment and spectral (UV-Vis, FT-IR, 1 H NMR, 13 C NMR and FAB-mass) data. NMR spectra indicate that there is rapid rotation of the cyclopentadienyl ring around the metal-ring axis at 25 °C. Studies were conducted to assess the growth inhibiting potential of the ligands and complexes against various bacterial strains. The complexes are found to be potent bactericides than the ligands.