Abstract
A novel series of Schiff base metal complexes of the type [M(L)2].nH2O, where L= 2-(α-methylsalicylidenehydrazino) benzimidazole (L1), 2-(α-phenylsalicylidenehydrazino)benzimidazole (L2), 2-(o-vanillinidenehydrazino)benzimidazole (L3), M = Cu(II), Co(II), Ni(II) and Zn(II), have been synthesized and characterized. The results are in consistent with tridentate chelation of ligand with azomethine nitrogen, ring nitrogen and a deprotonated phenolic oxygen atom. All these compounds have been screened for their antibacterial activities against B. subtilis, B. stearothermophilus, E. coli and S. typhi. KEY WORDS: Schiff base, Metal complexes, Spectral studies, Thermal studies, Kinetic studies, Antibacterial studies Bull. Chem. Soc. Ethiop. 2018, 32(3), 437-450. DOI: https://dx.doi.org/10.4314/bcse.v32i3.3
Highlights
Benzimidazole is a bicyclic compound having imidazole ring containing two nitrogen atoms at alternate positions fused to the benzene ring
Most of the complexes contain water molecules in their lattice, which certainly do not participate in coordination to the central metal ions as indicated from their thermal behavior
The octahedral geometry of all the complexes are established with tridentate chelation of ligand with azomethine nitrogen, ring nitrogen and oxygen atoms
Summary
Benzimidazole is a bicyclic compound having imidazole ring containing two nitrogen atoms at alternate positions fused to the benzene ring. It is an important biologically active heterocyclic compound. The chemistry of benzimidazole and its derivatives has been of great interest to medicinal chemists owing to their remarkable antimicrobial [1], antibacterial [2], antioxidant [3], anticancer [4], anthelmintic [5], cytotoxic [6], analgesic [7], antiulcer [8], antiviral [9] and anticonvulsant [10] activities. The antifungal [11], antimicrobial [12], antioxidant [13] and catalytic [14] activities of transition metal complexes with benzimidazole have been extensively studied. In recent years considerable attention has been paid to these metal complexes because of their contribution to cancer therapy [18,19]
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