Synthesis, Spectral, Thermal, In-vitro Antibacterial and Anticancer Activities of some Metal (II) Complexes of 3-(-1-(4-methoxy-6-methyl)-2- pyrimidinylimino)methyl-2-napthol

Abstract

The synthesis, spectroscopic (IR, electronic, 1 HNMR and mass), magnetic, thermal and conductance measurements with in-vitro antibacterial and anticancer evaluation on Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Pd(II) complexes of the Schiff base, 3-(-1-(4methoxy-6-methyl)-2-pyrimidinylimino)methyl-2-napthol are reported. The ligand coordinates through the azomethine N and napthol O atoms, resulting in an N 2O2 chromophore around the central metal atom. The room temperature magnetic moment, thermal, IR and electronic spectral measurements are consistent with the adoption of a 4-coordinate square planar/ tetrahedral geometry for the Co(II), Cu(II), Ni(II), Zn(II) and Pd(II) complexes; and a 6-coordinate octahedral geometry for the Mn(II) complex, with water occupying the fifth and sixth coordination sites. The complexes are magnetically dilute and non-electrolyte in DMSO. The in-vitro antibacterial studies show that the complexes are more active than the ligand and the Cu(II) complex exhibits a broadspectrum antibacterial activity against Enterococcus cloacae , Serratia liquefaciens ,