Synthesis, spectral study and antimicrobial activity of bismuth(III) 3(2′-hydroxyphenyl)-5-(4-substituted phenyl) pyrazolinates

Abstract

Dichlorobismuth(III) pyrazolinates and chlorobismuth(III) dipyrazolinates of the type BiCl2(C15H12N2OX) and BiCl(C15H12N2OX)2 have been synthesized in dry benzene by reaction of BiCl3 and the sodium salt of pyrazoline in 1 : 1 and 1 : 2 molar ratios at elevated temperature [C15H12N2OX = 3(2′-hydroxyphenyl)-5-(4-X-substituted phenyl) pyrazoline and X = H in compounds 1, 5, CH3 in 2, 6, OCH3 in 3, 7 and Cl in 4, 8, respectively]. These newly synthesized derivatives have been characterized by elemental analysis (C, H, N, Cl and Bi), molecular weight measurements and spectral (IR, 1H NMR, 13C NMR) studies. Selected compounds screened against different bacteria and fungi show potential antibacterial and antifungal activities.