Synthesis, Spectral Properties And Anticancer Studies of Novel Hetrocyclic Azo Dye Ligand Derived From 2-Amino-5-methyl thiazole with Some Transition Metal Complexes

Abstract

This research included preparation of the thiazolyl azo ligand 2-[2-- (5-Methyl thiazolyl)azo]-4-Ethoxy phenol (MeTAEP) and their metal complexes which was prepared by coupling of diazonium salt produced from diazonited 2-amino-5-methyl thiazole and 4-Ethoxy phenol, New series of chelate complexes of Cu(II), Ag(I) and Au(III) metal ions were also prepared by mixing solution of metal salts with solution of ligand at mole ratio[ M:L] [1:2] for Cu(II) and [1:1] for Ag(I) and Au(III) metal ions. The synthesized compounds were confirmed by elemental analysis, molar conductance measurments, magnetic susceptibility, Mass spectrum, 1H- NMR,13C- NMR, FTIR, UV-Visb., (TGA), FESEM and X-ray diffraction studies. The biological activity of thiazolyl azo dye ligand and its complexes were tested against the sensitive organisms Escherichia coli (gram negative), streptococcus (gram positive) as antibacterial and Aspergillus Niger and Penicillium. sp as antifungal, The anticancer activity of the(MeTAEP), Ag(I) and Au(III) complexes were screened for in vitro; antitumor activity against human breast cancer.