Synthesis, Spectral Interpretation, and Biological Efficiency of Azo Colorants Derived from Sulfadiazine Moiety

Abstract

The simple, economic, and conventional diazo-coupling method was developed for the synthesis of five different scaffolds of sulfadiazine incorporated azo dyes in acidic medium at chilled condition. The structural aspects of the prepared azo dyes were confirmed by various physical and spectroscopic techniques such as elemental analysis, electronic absorption studies, infrared, nuclear magnetic resonance (1H and 13C), and mass spectrometry. The electronic absorption study indicates that all the prepared azo dyes possess excellent coloring properties and it is supported by its molar absorptivity values. Further, these azo colorants were examined for different biological studies such as antimicrobial assay, radical scavenging, antituberculosis, anti-inflammatory, and DNA cleavage studies. From the results, all the studied azo dyes showed provoked and proficient biological efficacy against the tested assays.