Synthesis, spectral characterizations and biological applications of novel 3-[(E)-(4, 6-dihydroxy pyrimidin-5-yl)diazenyl]-4-methylbenzoic acid azo Dye and their derivatives

Abstract

Novel derivatives of Amino-methylbenzoic acid and Pyrimidine-4,6-diol based heterocyclic azo dyes (5–7) were reported. Synthesis was carried out by diazotization of amino-methylbenzoic acid (1) and followed by coupling with different derivatives of Pyrimidine-4,6-diol based coupling components such as Pyrimidine-4,6-diol(2), 2-methyl pyrimidine-4,6-diol(3), 2-aminopyrimidine-4,6-diol(4) under suitable experimental condition. The azo dyes obtained are orange-red in color and they are characterized by various analytical methods like IR, UV–Vis, 1H NMR, 13C NMR and Mass spectral techniques etc. The synthesized compounds were screened for their biological activities and the result was compared with the standards