Abstract
AbstractLopinavir (LPV) intermediate, a core unit of the HIV‐protease inhibitor is phosphorylated and screened for their binding efficacy with the Hemagglutinin‐Neuraminidase (HN) protein of Newcastle disease virus (NDV) and of VP7 protein of Bluetongue virus (BTV). The docking simulations were encouraged for their synthesis and screened their antiviral activity against NDV in the Chicken Embryonated eggs. The compounds which have exhibited higher binding energy were selected for antiviral evaluation on target pathogens such as NDV and BTV using in in ovo and in vitro methods. The results revealed that the compounds, 5a, 5b, 5i and 5j showed good activity against NDV and 5a, 5b, 5g and 5j exhibited noble antiviral activity against BTV in both in ovo and in vitro than the remaining title compounds.
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