Abstract
In this research, two new hydrazone derivatives; namely compound 1 (N'-(4-((2-hydroxyethyl)(methyl)amino) benzylidene)nicotinohydrazide) and compound 2 (N'-(4-((2-hydroxyethyl)(methyl)amino) benzylidene)isonicotinohydrazide), were designed, successfully synthesized with high purity by treatment of N-methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde with nicotinic hydrazide and isoniazid, respectively. Spectroscopic characterization of the synthesized compounds was carried out by using FT-IR, UV–Vis, HRMS, 1H- and 13C- NMR spectroscopic techniques, and elemental analysis (C, H, N). For the synthesized compounds, important quantum chemical parameters like frontier orbital energies, hardness, softness, chemical potential, back-donation energy, first electrophilicity index, second electrophilicity index, electrodonating power, electroaccepting power were calculated and the relations with the chemical stability of these parameters were discussed as detailed. Additionally, anticancer properties of the mentioned compounds were analyzed with the help of Molecular Docking studies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
